Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Monsalve GC et al. (2018) Genetics "A New Tool for Inducible Gene Expression in Caenorhabditis elegans."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Monsalve GC et al. (2018) Genetics "A New Tool for Inducible Gene Expression in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    30504365
    DOI:
    10.1534/genetics.118.301705
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00055873

    Monsalve GC, Yamamoto KR, & Ward JD (2018). A New Tool for Inducible Gene Expression in Caenorhabditis elegans. Genetics. doi:10.1534/genetics.118.301705

    Controlling protein activity and localization is a key tool in modern biology. Mammalian steroid receptor ligand-binding domains (LBDs) fusions have been used in a range of organisms and cell-types to inactivate proteins of interest until the cognate steroid ligand is applied. Here, we demonstrate that the glucocorticoid receptor LBD confers ligand-gated control of a heterologous gene expression system (Q system) and the DAF-16 transcription factor in <i>C. elegans</i> These experiments demonstrate provide a powerful tool for temporal control of protein activity, and will bolster existing tools used to modulate gene expression and protein activity in this animal.


    Tip: Seeing your name marked red? Please help us identify you.