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Resources » Paper

Plaisier AP et al. (1995) J Infect Dis "Irreversible effects of ivermectin on adult parasites in onchocerciasis patients in the Onchocerciasis Control Programme in West Africa."

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  • Comments on Plaisier AP et al. (1995) J Infect Dis "Irreversible effects of ivermectin on adult parasites in onchocerciasis patients in the Onchocerciasis Control Programme in West Africa." (0)

  • Overview

    PMID:
    7797912
    DOI:
    10.1093/infdis/172.1.204
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00055578

    Plaisier AP, Alley ES, Boatin BA, Van Oortmarssen GJ, Remme H, de Vlas SJ, Bonneux L, & Habbema JD (1995). Irreversible effects of ivermectin on adult parasites in onchocerciasis patients in the Onchocerciasis Control Programme in West Africa. J Infect Dis, 172, 204-10. doi:10.1093/infdis/172.1.204

    Ivermectin is an effective drug for the treatment of human onchocerciasis, a disease caused by the parasitic filarial nematode Onchocerca volvulus. When humans are treated, the microfilariae normally found in the skin are rapidly and very nearly completely eliminated. Nonetheless, after a delay, microfilariae gradually reappear in the skin. This study is concerned with the causes of this delay. Hypotheses are tested by comparing the results of model calculations with skin microfilaria counts collected from 114 patients during a trial of five annual treatments in the focus area of Asubende, Ghana. The results obtained strongly suggest that annual treatment with ivermectin causes an irreversible decline in microfilariae production of approximately 30%/treatment. This result has important implications for public health strategies designed to eliminate onchocerciasis as a significant health hazard.

    Authors: Plaisier AP, Alley ES, Boatin BA, Van Oortmarssen GJ, Remme H, de Vlas SJ, Bonneux L, Habbema JD


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