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Resources » Paper

Guerrero-Rubio MA et al. (2019) Food Chem "Extension of life-span using a RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans."

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  • Overview

    PMID:
    30373018
    DOI:
    10.1016/j.foodchem.2018.09.067
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00055523

    Guerrero-Rubio MA, Hernandez-Garcia S, Garcia-Carmona F, & Gandia-Herrero F (2019). Extension of life-span using a RNAi model and in vivo antioxidant effect of Opuntia fruit extracts and pure betalains in Caenorhabditis elegans. Food Chem, 274, 840-847. doi:10.1016/j.foodchem.2018.09.067

    Betalains are nitrogenous plant pigments known for their high antioxidant capacity. For the first time, this antioxidant nature has been studied in an in vivo system using the model organism Caenorhabditis elegans. The oxidative stress caused in the fluorescent strain TJ375 (hsp-16.2::GFP) was reversed by the presence of both natural and semi-synthetic betalains, with an ED<sub>50</sub> value around 25M for betacyanins and up to 10M for betaxanthins, with indicaxanthin, the major pigments in prickly pear fruits, as the most effective betalain. The effect of model betalains on the lifespan of the wild-type N2 strain was carefully studied using the automatic platform "Lifespan Machine". In a search for different approaches to suppress progeny, pop-1 RNAi was used to avoid FUdR use. The presence of betalains in the medium, both as pure compounds and as enriched Opuntia extracts significantly increased the lifespan of C. elegans.


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