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Resources » Paper

MacDonald AS et al. (1999) Pathobiology "Suppressive antigen-presenting cells in Helminth infection."

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  • Overview

    PMID:
    10725799
    DOI:
    10.1159/000028107
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00054658

    MacDonald AS, Loke P, & Allen JE (1999). Suppressive antigen-presenting cells in Helminth infection. Pathobiology, 67, 265-8. doi:10.1159/000028107

    Infection with filarial nematodes is commonly associated with a failure of T cells to proliferate in response to parasite antigen. We have investigated the possibility that antigen-presenting cells recruited during filarial infection are responsible for impairment of T cell function. We have found that the human filarial parasite Brugia malayi, when implanted into the peritoneal cavity of mice, recruits a population of adherent cells that actively block the proliferation of T cells. Phenotypic analysis of the recruited cells reveals large numbers of both macrophages and eosinophils and cell sorting experiments demonstrate that these antiproliferative cells are Mac-1-positive. Studies in gene-deficient mice have demonstrated that proliferative suppression is dependent on the in vivo production of IL-4 but not IL-5 or IL-10, while suppression in vitro is not mediated by any known antiproliferative factor. Our results suggest that helminth infection can lead to the development and/or recruitment of an IL-4-dependent macrophage population that mediates suppression via a novel mechanism.


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