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Resources » Paper

Hawk JD et al. (2018) Neuron "Integration of Plasticity Mechanisms within a Single Sensory Neuron of C.elegans Actuates a Memory."

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  • Comments on Hawk JD et al. (2018) Neuron "Integration of Plasticity Mechanisms within a Single Sensory Neuron of C.elegans Actuates a Memory." (0)

  • Overview

    PMID:
    29307713
    DOI:
    10.1016/j.neuron.2017.12.027
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00053556

    Hawk JD, Calvo AC, Liu P, Almoril-Porras A, Aljobeh A, Torruella-Suarez ML, Ren I, Cook N, Greenwood J, Luo L, Wang ZW, Samuel ADT, & Colon-Ramos DA (2018). Integration of Plasticity Mechanisms within a Single Sensory Neuron of C.elegans Actuates a Memory. Neuron. doi:10.1016/j.neuron.2017.12.027

    Neural plasticity, the ability of neurons to change their properties in response to experiences, underpins the nervous system's capacity to form memories and actuate behaviors. How different plasticity mechanisms act together invivo and at a cellular level to transform sensory information into behavior is not well understood. We show that in Caenorhabditis elegans two plasticity mechanisms-sensory adaptation and presynaptic plasticity-act within a single cell to encode thermosensory information and actuate a temperature preference memory. Sensory adaptation adjusts the temperature range of the sensory neuron (called AFD) to optimize detection of temperature fluctuations associated with migration. Presynaptic plasticity in AFD is regulated by the conserved kinase nPKC and transforms thermosensory information into a behavioral preference. Bypassing AFD presynaptic plasticity predictably changes learned behavioral preferences without affecting sensory responses. Our findings indicate that two distinct neuroplasticity mechanisms function together through a single-cell logic system to enact thermotactic behavior.

    Authors: Hawk JD, Calvo AC, Liu P, Almoril-Porras A, Aljobeh A, Torruella-Suarez ML, Ren I, Cook N, Greenwood J, Luo L, Wang ZW, Samuel ADT, Colon-Ramos DA


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