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Resources » Paper

Alqadah A et al. (2017) Dev Dyn "Asymmetric development of the nervous system."

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  • Overview

    PMID:
    28940676
    DOI:
    10.1002/dvdy.24595
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00053132

    Alqadah A, Hsieh YW, Morrissey ZD, & Chuang CF (2017). Asymmetric development of the nervous system. Dev Dyn. doi:10.1002/dvdy.24595

    The human nervous system consists of seemingly symmetric left and right halves. However, closer observation of the brain reveals anatomical and functional lateralization. Defects in brain asymmetry correlate with several neurological disorders, yet our understanding of the mechanisms used to establish lateralization in the human central nervous system is extremely limited. Here, we review left-right asymmetries within the nervous system of humans and several model organisms, including rodents, zebrafish, chickens, Xenopus, Drosophila, and the nematode Caenorhabditis elegans. Comparing and contrasting mechanisms used to develop left-right asymmetry in the nervous system can provide insight into how the human brain is lateralized. This article is protected by copyright. All rights reserved.


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