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Resources » Paper

Piggott, C.A. et al. (2017) International Worm Meeting "Investigating the roles of membrane contact site proteins in axon regeneration."

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  • Comments on Piggott, C.A. et al. (2017) International Worm Meeting "Investigating the roles of membrane contact site proteins in axon regeneration." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052731

    Piggott, C.A., Wu, Z., & Jin, Y. (2017). Investigating the roles of membrane contact site proteins in axon regeneration presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Axons are vital for the function of the nervous system as they transmit neuronal signals to their targets. During development of the nervous system, axons readily grow and make precise connections, but that ability is lost as animals mature into adults. It is unclear which signaling pathways promote and restrain axon growth throughout development into adulthood. Through a systematic genetic screen using laser axotomy of PLM neurons, we identified several genes that are predicted to function at interorganellar membrane contacts. Loss of function in these genes display differential effects on PLM axon regeneration. Among them, we have focused on esyt-2, a member of the extended synaptotagmin family, which have been shown to maintain membrane contact sites between the endoplasmic reticulum (ER) and plasma membrane. We found that ESYT-2 localizes to putative ER-plasma membrane contact sites in neurons. Inducing injury by laser axotomy causes an immediate relocalization of ESYT-2, which may represent a change in membrane contact sites in response to injury. We are currently investigating the mechanism of how membrane contact site protein may play an important role in axon regeneration.

    Affiliations:
    - Howard Hughes Medical Institute, University of California San Diego, La Jolla, CA
    - Division of Biological Sciences, University of California San Diego, La Jolla, CA


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