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Resources » Paper

Santhosh, Rasitha et al. (2017) International Worm Meeting "Insulin pathway differentially alters learning and memory in Caenorhabditis elegans."

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  • Comments on Santhosh, Rasitha et al. (2017) International Worm Meeting "Insulin pathway differentially alters learning and memory in Caenorhabditis elegans." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052605

    Santhosh, Rasitha, Nair, Agrima, Mangalath, Aswathy, Raj, Vishnu, Suresh, Swathy, & Thekkuveettil, Anoopkumar (2017). Insulin pathway differentially alters learning and memory in Caenorhabditis elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Dauer constitutive (Daf-c) mutants of C. elegans have been extensively studied as a model to understand the regulatory molecules involved in organismal development and longivity. Recently one of the longevity extending factor, insulin/IGF-1 receptor mutant Daf-2 have been reported to have enhanced learning and memory. To elucidate this further, we tested butanone-associated appetitive learning in insulin mutant ins-1 and found enhanced learning in this strain similar to that of Daf-2. However, daf-16, akt-1 and age-1 mutants did not show a significant reduction in learning, suggesting the limited involvement of Daf-2 downstream pathways in learning and memory. Surprisingly, associative-learning in post-dauer N2 strains showed a significant reduction in learning and memory paradigm compared to the control wild-type adults. Furthermore, 24-hour starved worms also showed significantly low learning and memory. These results suggest that the learning deficiency could be linked to the environment or epigenetic factors during early development of an organism. Besides, AWC sensory neuron, which is known to express the insulin receptor Daf-2 might have a regulatory role in integrating various cues to determine the learning and memory capabilities of the organism.

    Affiliation:
    - Molecular Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, IN


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