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Resources » Paper

Mangalath, Aswathy et al. (2017) International Worm Meeting "Imprinting enhances learning and memory in C. elegans."

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052604

    Mangalath, Aswathy, Raj, Vishnu, Nair, Agrima, Santhosh, Rasitha, & Thekkuveettil, Anoopkumar (2017). Imprinting enhances learning and memory in C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Imprinted memory, thought to be an epigenetic phenomenon, develops during a critical period in the early development. This form of memory is an unconditional learning and can last even in adulthood. The role of imprinting in normal learning and memory process is however not known. We addressed this question by inducing imprinted olfactory memory in C. elegans and assayed for its impact in olfactory learning and memory. Imprinted wild type N2 worms showed a better learning and memory compared to naive. Sra-11 mutants, a known imprinting defective strain, however, showed significantly better learning. However, cima-1 mutants, defective in AIY presynaptic G-protein coupled receptor showed both imprinting and learning defect. These results suggested that though both imprinting and learning share same neuronal circuits, the molecular pathways could be unique in both. Besides, results suggest that imprinting involves both sra-11 and cima-1 receptors localized at post- and pre-synaptic terminal of AIY interneuron, respectively, connecting AWC and RIA.

    Affiliation:
    - Molecular Medicine, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, IN


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