Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Tan, Trudy et al. (2017) International Worm Meeting "Thermotaxis navigational modeling and virtual reality investigation."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Tan, Trudy et al. (2017) International Worm Meeting "Thermotaxis navigational modeling and virtual reality investigation." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052598

    Tan, Trudy, Huang, Rebecca, Watson, Sonya, Yamada, Mandi, Mendoza, Steve, Carmona, Javier, Liu, Junliang, D'Orazio, Etta, Mai, Phat, Jin, Suying, Park, Jane, Kim, Ted, Zadoorian, Arbi, Yen, Jessica, Narain, Shreya, Yang, Karen, & Arisaka, Katsushi (2017). Thermotaxis navigational modeling and virtual reality investigation presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Caenorhabditis elegans exhibit a well-characterized host of thermosensory behaviors necessary for efficient navigation, foraging, and survival in the natural environment. Many of the neural structures responsible for temperature sensing have evolved to exceptional sensitivity over time, giving rise to cognitively complex, deterministic behaviors such as bias orientation and 90 degree turning. In order to better comprehend the underlying neural circuitry responsible for such behaviors, multiple PID-controlled hardware systems have been constructed to generate and control various thermal gradient conditions within 0.05 degrees C, over durations of ~ 30 minutes. Additionally, an IR laser-based thermosensory system has been fabricated, to provide spatiotemporally controlled thermal stimulus at a highly localized region of the worm's body, enabling the establishment of a virtual thermal environment on which the worm can behave. Using these tools, we have investigated several intricacies of C. elegans' response to temperature, including the mechanism governing 90 degree turns and biased orientation during negative thermotaxis. Making use of line confocal calcium imaging microscopy methods, the dynamics of the AFD sensory neuron and the AIY interneuron were observed, yielding multiple noteworthy datasets. Custom-written MatLab image processing tools based on Goodman and NEMO were utilized to conduct a systematic motional analysis in a variety of experimental thermal conditions. This poster aims to outline the some of these recent advancements in thermotaxis investigation in the Elegant Mind Club, along with preliminary supporting datasets, on a case-by-case basis.

    Authors: Tan, Trudy, Huang, Rebecca, Watson, Sonya, Yamada, Mandi, Mendoza, Steve, Carmona, Javier, Liu, Junliang, D'Orazio, Etta, Mai, Phat, Jin, Suying, Park, Jane, Kim, Ted, Zadoorian, Arbi, Yen, Jessica, Narain, Shreya, Yang, Karen, Arisaka, Katsushi

    Affiliation:
    - University of California Los Angeles, Los Angeles, CA


    Tip: Seeing your name marked red? Please help us identify you.