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Resources » Paper

Posner, Rachel et al. (2017) International Worm Meeting "Gene regulation via non-cell autonomous acting small RNAs in C. elegans."

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  • Comments on Posner, Rachel et al. (2017) International Worm Meeting "Gene regulation via non-cell autonomous acting small RNAs in C. elegans." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052472

    Posner, Rachel, Star, Ekaterina, Anava, Sarit, Azmon, Eran, Bracha, Shahar, Gingold, Hila, Hobert, Oliver, & Rechavi, Oded (2017). Gene regulation via non-cell autonomous acting small RNAs in C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Exposure of C. elegans to artificial dsRNA can trigger exogenous small RNA-mediated silencing that transmits from somatic cells to the germline, and persists for multiple generations. However, it is unknown whether endogenous types of small RNAs (miRNAs, piRNAs and endo-siRNAs) produce systematic responses and what type of effect they may have on gene regulation. Our recent results suggest that endogenous siRNAs act in a non-cell autonomous manner, orchestrating gene silencing between tissues. We will present a dissection of the major components of the RNAi pathway required for non-cell autonomous gene regulation by endo-siRNAs and provide evidence possibly linking the regulation of physiological phenotypes to small RNAs mobilizing between tissues.

    Authors: Posner, Rachel, Star, Ekaterina, Anava, Sarit, Azmon, Eran, Bracha, Shahar, Gingold, Hila, Hobert, Oliver, Rechavi, Oded

    Affiliations:
    - Department of Neurobiology, Wise Faculty of Life Sciences & Sagol School for Neuroscience, Tel Aviv University, Tel Aviv, Israel
    - Columbia University Medical Center, Department of Biochemistry and Molecular Biophysics, Howard Hughes Medical Institute, New York


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