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Resources » Paper

Zhang, Y. et al. (2017) International Worm Meeting "The intrafagellar transportation of sensory cilia is impaired in aged C. elegans."

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  • Comments on Zhang, Y. et al. (2017) International Worm Meeting "The intrafagellar transportation of sensory cilia is impaired in aged C. elegans." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00052096

    Zhang, Y., & Shen, Y. (2017). The intrafagellar transportation of sensory cilia is impaired in aged C. elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Sensory functions decline with age. As in many other organisms, sensory functions depend on cilia of sensory neurons in C. elegans. Most major tissues of C. elegans, including body wall muscle, intestine and reproductive system, undergo dramatic changes with ageing. The ageing nervous system undergoes more subtle changes such as dendritic restructuring and synaptic deterioration. However, the changes of cilia in sensory neurons with age remain poorly understood. Sensory cilia are only found at the dendritic endings of sensory neurons in C. elegans, including amphid and phasmid cilia. Cilia functions depend on intraflagellar transport (IFT), which delivers cilia proteins into and within sensory cilia. In order to examine the IFT trafficking in C. elegans in vivo, we tagged endogenous IFT proteins with GFP using CRISPR/Cas9. Using live imaging microscopy to monitor the velocity and frequency of IFT components in young and aged worms, we show that ageing impaired many IFT components in velocity and frequency. Understanding the mechanisms underlying the decline of IFT functions in cilia will help identify cellular factors that protect the cilia structure and function during normal ageing and in disease states.

    Affiliation:
    - Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, CN


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