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Resources » Paper

Brantley S et al. (2017) Biochem Biophys Res Commun "Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening."

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  • Comments on Brantley S et al. (2017) Biochem Biophys Res Commun "Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening." (0)

  • Overview

    PMID:
    28733033
    DOI:
    10.1016/j.bbrc.2017.07.100
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00051535

    Brantley S, Cotten SW, Lamson DR, Smith GR, Liu R, & Williams KP (2017). Discovery of small molecule inhibitors for the C. elegans caspase CED-3 by high-throughput screening. Biochem Biophys Res Commun. doi:10.1016/j.bbrc.2017.07.100

    C.elegans has been widely used as a model organism for programmed cell death and apoptosis. Although, the CED-3 caspase is the primary effector of cell death in C. elegans, no selective inhibitors have been identified. Utilizing high-throughput screening with recombinant C. elegans CED-3 protein, we have discovered and confirmed 21 novel small molecule inhibitors. Six compounds had IC50 values<10M. From these, four distinct chemotypes were identified. The inhibitor scaffolds described here could lead to the development of selective molecular probes to facilitate our understanding of programmed cell death in this model organism.


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