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Resources » Paper

Wang YA et al. (2017) Hum Genomics "Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans."

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  • Comments on Wang YA et al. (2017) Hum Genomics "Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans." (0)

  • Overview

    PMID:
    28545550
    DOI:
    10.1186/s40246-017-0108-4
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00051283

    Wang YA, Kammenga JE, & Harvey SC (2017). Genetic variation in neurodegenerative diseases and its accessibility in the model organism Caenorhabditis elegans. Hum Genomics, 11, 12. doi:10.1186/s40246-017-0108-4

    BACKGROUND: Neurodegenerative diseases (NGDs) such as Alzheimer's and Parkinson's are debilitating and largely untreatable conditions strongly linked to age. The clinical, neuropathological, and genetic components of NGDs indicate that neurodegeneration is a complex trait determined by multiple genes and by the environment. MAIN BODY: The symptoms of NGDs differ among individuals due totheir genetic background, and this variation affects the onset and progression of NGD and NGD-like states. Such genetic variation affects the molecular and cellular processes underlying NGDs, leading to differential clinical phenotypes. So far, we have a limited understanding of the mechanisms of individual background variation. Here, we consider how variation between genetic backgrounds affects the mechanisms of aging and proteostasis in NGD phenotypes. We discuss how the nematode Caenorhabditis elegans can be used to identify the role of variation between genetic backgrounds. Additionally, we review advances in C. elegans methods that can facilitate the identification of NGD regulators and/or networks. CONCLUSION: Genetic variation both in disease genes and in regulatory factors that modulate onset and progression of NGDs are incompletely understood. The nematode C. elegans represents avaluable system in which to address such questions.


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