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Resources » Paper

Krauchunas AR et al. (2016) Worm "Marriage shrines and worms impacting our understanding of mammalian fertilization."

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  • Overview

    PMID:
    27695649
    DOI:
    10.1080/21624054.2016.1184389
    Status:
    Publication type:
    Comment
    WormBase ID:
    WBPaper00050294

    Krauchunas AR, & Singson A (2016). Marriage shrines and worms impacting our understanding of mammalian fertilization. Worm, 5, e1184389. doi:10.1080/21624054.2016.1184389

    Genetic approaches in C. elegans are complementing the biochemical and antibody based strategies traditionally used to study the molecular underpinnings of fertilization in other organisms. A pair of worm studies, one based on forward genetics and one based on reverse genetics, converge on the sperm immunoglobulin superfamily molecule SPE-45. Loss of spe-45 function leads to the production of sperm that cannot fertilize wild-type eggs. This is a strikingly similar phenotype as those seen in mice lacking the immunoglobulin superfamily protein Izumo1. This work sets the stage for leveraging the power of the C. elegans model system to learn more about Izumo-like molecular function but also for the discovery of additional deeply conserved components of fertility pathways.


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