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Resources » Paper

Li J et al. (2016) Genes Dev "E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response."

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  • Comments on Li J et al. (2016) Genes Dev "E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response." (0)

  • Overview

    PMID:
    27688402
    DOI:
    10.1101/gad.283317.116
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00050199

    Li J, Chauve L, Phelps G, Brielmann RM, & Morimoto RI (2016). E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Genes Dev. doi:10.1101/gad.283317.116

    Heat-shock factor (HSF) is the master transcriptional regulator of the heat-shock response (HSR) and is essential for stress resilience. HSF is also required for metazoan development; however, its function and regulation in this process are poorly understood. Here, we characterize the genomic distribution and transcriptional activity of Caenorhabditis elegans HSF-1 during larval development and show that the developmental HSF-1 transcriptional program is distinct from the HSR. HSF-1 developmental activation requires binding of E2F/DP to a GC-rich motif that facilitates HSF-1 binding to a heat-shock element (HSE) that is degenerate from the consensus HSE sequence and adjacent to the E2F-binding site at promoters. In contrast, induction of the HSR is independent of these promoter elements or E2F/DP and instead requires a distinct set of tandem canonical HSEs. Together, E2F and HSF-1 directly regulate a gene network, including a specific subset of chaperones, to promote protein biogenesis and anabolic metabolism, which are essential in development.


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