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Resources » Paper

Wang Y et al. (2016) Nat Commun "Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans."

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  • Comments on Wang Y et al. (2016) Nat Commun "Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    27581092
    DOI:
    10.1038/ncomms12569
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00050077

    Wang Y, Zhang Y, Chen L, Liang Q, Yin XM, Miao L, Kang BH, & Xue D (2016). Kinetics and specificity of paternal mitochondrial elimination in Caenorhabditis elegans. Nat Commun, 7, 12569. doi:10.1038/ncomms12569

    In most eukaryotes, mitochondria are inherited maternally. The autophagy process is critical for paternal mitochondrial elimination (PME) in Caenorhabditis elegans, but how paternal mitochondria, but not maternal mitochondria, are selectively targeted for degradation is poorly understood. Here we report that mitochondrial dynamics have a profound effect on PME. A defect in fission of paternal mitochondria delays PME, whereas a defect in fusion of paternal mitochondria accelerates PME. Surprisingly, a defect in maternal mitochondrial fusion delays PME, which is reversed by a fission defect in maternal mitochondria or by increasing maternal mitochondrial membrane potential using oligomycin. Electron microscopy and tomography analyses reveal that a proportion of maternal mitochondria are compromised when they fail to fuse normally, leading to their competition for the autophagy machinery with damaged paternal mitochondria and delayed PME. Our study indicates that mitochondrial dynamics play a critical role in regulating both the kinetics and the specificity of PME.

    Authors: Wang Y, Zhang Y, Chen L, Liang Q, Yin XM, Miao L, Kang BH, Xue D


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