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Resources » Paper

Dietrich N et al. (2016) Arch Biochem Biophys "Insights into zinc and cadmium biology in the nematode C. elegans."

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  • Comments on Dietrich N et al. (2016) Arch Biochem Biophys "Insights into zinc and cadmium biology in the nematode C. elegans." (0)

  • Overview

    PMID:
    27261336
    DOI:
    10.1016/j.abb.2016.05.021
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00049634

    Dietrich N, Tan CH, Cubillas C, Earley BJ, & Kornfeld K (2016). Insights into zinc and cadmium biology in the nematode C. elegans. Arch Biochem Biophys. doi:10.1016/j.abb.2016.05.021

    Zinc is an essential metal that is involved in a wide range of biological processes, and aberrant zinc homeostasis is implicated in multiple human diseases. Cadmium is chemically similar to zinc, but it is a nonessential environmental pollutant. Because zinc deficiency and excess are deleterious, animals require homeostatic mechanisms to maintain zinc levels in response to dietary fluctuations. The nematode Caenorhabditis elegans is emerging as a powerful model system to investigate zinc trafficking and homeostasis as well as cadmium toxicity. Here we review genetic and molecular studies that have combined to generate a picture of zinc homeostasis based on the transcriptional control of zinc transporters in intestinal cells. Furthermore, we summarize studies of cadmium toxicity that reveal intriguing parallels with zinc biology.


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