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Resources » Paper

Dong X et al. (2016) Elife "Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions."

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  • Comments on Dong X et al. (2016) Elife "Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions." (0)

  • Overview

    PMID:
    26974341
    DOI:
    10.7554/eLife.11008
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00049350

    Dong X, Chiu H, Park YJ, Zou W, Zou Y, Ozkan E, Chang C, & Shen K (2016). Precise regulation of the guidance receptor DMA-1 by KPC-1/Furin instructs dendritic branching decisions. Elife, 5. doi:10.7554/eLife.11008

    Extracellular adhesion molecules and their neuronal receptors guide the growth and branching of axons and dendrites. Growth cones are attracted to intermediate targets, but they must switch their response upon arrival so that they can move away and complete the next stage of growth. Here, we show that KPC-1, a C. elegans Furin homolog, regulates the level of the branching receptor DMA-1 on dendrites by targeting it to late endosomes. In kpc-1 mutants, the level of DMA-1 is abnormally high on dendrites, resulting in trapping of dendrites at locations where a high level of the cognate ligand, the adhesion molecule SAX-7/L1, is present. The misregulation of DMA-1 also causes dendritic self-avoidance defects. Thus, precise regulation of guidance receptors creates flexibility of responses to guidance signals and is critical for neuronal morphogenesis.

    Authors: Dong X, Chiu H, Park YJ, Zou W, Zou Y, Ozkan E, Chang C, Shen K


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