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Resources » Paper

Nagashima T et al. (2016) Dev Biol "Dopamine regulates body size in Caenorhabditis elegans."

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  • Comments on Nagashima T et al. (2016) Dev Biol "Dopamine regulates body size in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    26921458
    DOI:
    10.1016/j.ydbio.2016.02.021
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00049285

    Nagashima T, Oami E, Kutsuna N, Ishiura S, & Suo S (2016). Dopamine regulates body size in Caenorhabditis elegans. Dev Biol, 412, 128-38. doi:10.1016/j.ydbio.2016.02.021

    The nervous system plays a critical role in the regulation of animal body sizes. In Caenorhabditis elegans, an amine neurotransmitter, dopamine, is required for the tactile perception of food and food-dependent behavioral changes, while its role in development is unknown. In this study, we show that dopamine negatively regulates body size through a D2-like dopamine receptor, DOP-3, in C. elegans. Dopamine alters body size without affecting food intake or developmental rate. We also found that dopamine promotes egg-laying, although the regulation of body size by dopamine was not solely caused by this effect. Furthermore, dopamine negatively regulates body size through the suppression of signaling by octopamine and Gq-coupled octopamine receptors, SER-3 and SER-6. Our results demonstrate that dopamine and octopamine regulate the body size of C. elegans and suggest a potential role for perception in addition to ingestion of food for growth.


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