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Resources » Paper

Berber S et al. (2016) Sci Rep "Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans."

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  • Comments on Berber S et al. (2016) Sci Rep "Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans." (0)

  • Overview

    PMID:
    26791749
    DOI:
    10.1038/srep19582
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00049134

    Berber S, Wood M, Llamosas E, Thaivalappil P, Lee K, Liao BM, Chew YL, Rhodes A, Yucel D, Crossley M, & Nicholas HR (2016). Homeodomain-Interacting Protein Kinase (HPK-1) regulates stress responses and ageing in C. elegans. Sci Rep, 6, 19582. doi:10.1038/srep19582

    Proteins of the Homeodomain-Interacting Protein Kinase (HIPK) family regulate an array of processes in mammalian systems, such as the DNA damage response, cellular proliferation and apoptosis. The nematode Caenorhabditis elegans has a single HIPK homologue called HPK-1. Previous studies have implicated HPK-1 in longevity control and suggested that this protein may be regulated in a stress-dependent manner. Here we set out to expand these observations by investigating the role of HPK-1 in longevity and in the response to heat and oxidative stress. We find that levels of HPK-1 are regulated by heat stress, and that HPK-1 contributes to survival following heat or oxidative stress. Additionally, we show that HPK-1 is required for normal longevity, with loss of HPK-1 function leading to a faster decline of physiological processes that reflect premature ageing. Through microarray analysis, we have found that HPK-1-regulated genes include those encoding proteins that serve important functions in stress responses such as Phase I and Phase II detoxification enzymes. Consistent with a role in longevity assurance, HPK-1 also regulates the expression of age-regulated genes. Lastly, we show that HPK-1 functions in the same pathway as DAF-16 to regulate longevity and reveal a new role for HPK-1 in development.

    Authors: Berber S, Wood M, Llamosas E, Thaivalappil P, Lee K, Liao BM, Chew YL, Rhodes A, Yucel D, Crossley M, Nicholas HR


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