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Resources » Paper

Dobrzynska A et al. (2016) Methods Enzymol "Lamin-Binding Proteins in Caenorhabditis elegans."

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  • Overview

    PMID:
    26778571
    DOI:
    10.1016/bs.mie.2015.08.036
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00049103

    Dobrzynska A, Askjaer P, & Gruenbaum Y (2016). Lamin-Binding Proteins in Caenorhabditis elegans. Methods Enzymol, 569, 455-83. doi:10.1016/bs.mie.2015.08.036

    The nuclear lamina, composed of lamins and numerous lamin-associated proteins, is required for mechanical stability, mechanosensing, chromatin organization, developmental gene regulation, mRNA transcription, DNA replication, nuclear assembly, and nuclear positioning. Mutations in lamins or lamin-binding proteins cause at least 18 distinct human diseases that affect specific tissues such as muscle, adipose, bone, nerve, or skin, and range from muscular dystrophies to lipodystrophy, peripheral neuropathy, or accelerated aging. Caenorhabditis elegans has unique advantages in studying lamin-binding proteins. These advantages include the low complexity of genes encoding lamin and lamin-binding proteins, advanced transgenic techniques, simple application of RNA interference, sophisticated genetic strategies, and a large collection of mutant lines. This chapter provides detailed and comprehensive protocols for the genetic and phenotypic analysis of lamin-binding proteins in C. elegans.


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