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Resources » Paper

Altintas O et al. (2015) BMB Rep "The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster."

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  • Comments on Altintas O et al. (2015) BMB Rep "The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster." (0)

  • Overview

    PMID:
    26698870
    DOI:
    10.5483/bmbrep.2016.49.2.261
    Status:
    Publication type:
    News
    WormBase ID:
    WBPaper00049036

    Altintas O, Park S, & Lee SV (2015). The role of insulin/IGF-1 signaling in the longevity of model invertebrates, C. elegans and D. melanogaster. BMB Rep. doi:10.5483/bmbrep.2016.49.2.261

    Insulin/insulin-like growth factor (IGF)-1 signaling (IIS) pathway regulates aging in many organisms ranging from simple invertebrates to mammals including humans. Many seminal discoveries regarding the roles of IIS in aging and longevity have been made by using the roundworm Caenorhabditis elegans and the fruit fly Drosophila melanogaster. In this review, we describe mechanisms by which various IIS components regulate aging in C. elegans and D. melanogaster. We also cover systemic and tissue-specific effects of the IIS components on the regulation of lifespan. We further discuss IIS-mediated physiological processes other than aging and its effects on human disease models focusing on findings that used C. elegans. As both C. elegans and D. melanogaster have been essential for key findings regarding the effects of IIS on organismal aging in general, these invertebrate models will continue to serve as workhorses to help our understanding of mammalian aging.


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