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Resources » Paper

Rangaraju S et al. (2015) Elife "Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality."

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  • Comments on Rangaraju S et al. (2015) Elife "Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality." (0)

  • Overview

    PMID:
    26623667
    DOI:
    10.7554/eLife.08833
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00048926

    Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, & Petrascheck M (2015). Suppression of transcriptional drift extends C. elegans lifespan by postponing the onset of mortality. Elife, 4, e08833. doi:10.7554/eLife.08833

    Longevity mechanisms increase lifespan by counteracting the effects of aging. However, whether longevity mechanisms counteract the effects of aging continually throughout life, or whether they act during specific periods of life, preventing changes that precede mortality is unclear. Here, we uncover transcriptional drift, a phenomenon that describes how aging causes genes within functional groups to change expression in opposing directions. These changes cause a transcriptome-wide loss in mRNA stoichiometry and loss of co-expression patterns in aging animals, as compared to young adults. Using Caenorhabditis elegans as a model, we show that extending lifespan by inhibiting serotonergic signals by the antidepressant mianserin attenuates transcriptional drift, allowing the preservation of a younger transcriptome into an older age. Our data are consistent with a model in which inhibition of serotonergic signals slows age-dependent physiological decline and the associated rise in mortality levels exclusively in young adults, thereby postponing the onset of major mortality.

    Authors: Rangaraju S, Solis GM, Thompson RC, Gomez-Amaro RL, Kurian L, Encalada SE, Niculescu AB, Salomon DR, Petrascheck M


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