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Resources » Paper

Verma S et al. (2015) IUBMB Life "Understanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organisms."

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  • Comments on Verma S et al. (2015) IUBMB Life "Understanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organisms." (0)

  • Overview

    PMID:
    26179888
    DOI:
    10.1002/iub.1393
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00048481

    Verma S, & Srikanth CV (2015). Understanding the complexities of Salmonella-host crosstalk as revealed by in vivo model organisms. IUBMB Life, 67, 482-97. doi:10.1002/iub.1393

    Foodborne infections caused by non-typhoidal Salmonellae, such as Salmonella enterica serovar Typhimurium (ST), pose a major challenge in the developed and developing world. With constant rise of drug-resistant strains, understanding the epidemiology, microbiology, pathogenesis and host-pathogen interactions biology is a mandatory requirement to enable health systems to be ready to combat these illnesses. Patient data from hospitals, at least from some parts of the world, have aided in epidemiological understanding of ST-mediated disease. Most of the other aspects connected to Salmonella-host crosstalk have come from model systems that offer convenience, genetic tractability and low maintenance costs that make them extremely valuable tools. Complex model systems such as the bovine model have helped in understanding key virulence factors needed for infection. Simple systems such as fruit flies and Caenorhabditis elegans have aided in identification of novel virulence factors, host pathways and mechanistic details of interactions. Some of the path-breaking concepts of the field have come from mice model of ST colitis, which allows genetic manipulations as well as high degree of similarity to human counterpart. Together, they are invaluable for correlating in vitro findings of ST-induced disease progression in vivo. The current review is a compilation of various advances of ST-host interactions at cellular and molecular levels that has come from investigations involving model organisms.


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