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Resources » Paper

Sharma R et al. (2014) Genes Dev "Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans."

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  • Comments on Sharma R et al. (2014) Genes Dev "Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans." (0)

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    PMID:
    25452271
    DOI:
    10.1101/gad.248864.114
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00046132

    Sharma R, Jost D, Kind J, Gomez-Saldivar G, van Steensel B, Askjaer P, Vaillant C, & Meister P (2014). Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans. Genes Dev, 28, 2591-6. doi:10.1101/gad.248864.114

    The adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites.

    Authors: Sharma R, Jost D, Kind J, Gomez-Saldivar G, van Steensel B, Askjaer P, Vaillant C, Meister P


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