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Resources » Paper

Ratnappan R et al. (2014) PLoS Genet "Germline signals deploy NHR-49 to modulate fatty-acid -oxidation and desaturation in somatic tissues of C. elegans."

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  • Comments on Ratnappan R et al. (2014) PLoS Genet "Germline signals deploy NHR-49 to modulate fatty-acid -oxidation and desaturation in somatic tissues of C. elegans." (0)

  • Overview

    PMID:
    25474470
    DOI:
    10.1371/journal.pgen.1004829
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00046079

    Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, & Ghazi A (2014). Germline signals deploy NHR-49 to modulate fatty-acid -oxidation and desaturation in somatic tissues of C. elegans. PLoS Genet, 10, e1004829. doi:10.1371/journal.pgen.1004829

    In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial -oxidation and fatty-acid desaturation. The coordinated augmentation of these processes is critical for germline-less animals to maintain their lipid stores and to sustain de novo fat synthesis during adulthood. Following germline ablation, NHR-49 is up-regulated in somatic cells by the conserved longevity determinants DAF-16/FOXO and TCER-1/TCERG1. Accordingly, NHR-49 overexpression in fertile animals extends their lifespan modestly. In fertile adults, nhr-49 expression is DAF-16/FOXO and TCER-1/TCERG1 independent although its depletion causes age-related lipid abnormalities. Our data provide molecular insights into how reproductive stimuli are integrated into global metabolic changes to alter the lifespan of the animal. They suggest that NHR-49 may facilitate the adaptation to loss of reproductive potential through synchronized enhancement of fatty-acid oxidation and desaturation, thus breaking down some fats ordained for reproduction and orchestrating a lipid profile conducive for somatic maintenance and longevity.

    Authors: Ratnappan R, Amrit FR, Chen SW, Gill H, Holden K, Ward J, Yamamoto KR, Olsen CP, Ghazi A


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