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Resources » Paper

Mizushima N (2014) Nat Cell Biol "Sugar modification inhibits autophagosome-lysosome fusion."

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    PMID:
    25434465
    DOI:
    10.1038/ncb3078
    Status:
    Publication type:
    Comment
    WormBase ID:
    WBPaper00046062

    Mizushima N (2014). Sugar modification inhibits autophagosome-lysosome fusion. Nat Cell Biol, 16, 1132-3. doi:10.1038/ncb3078

    Autophagy is an intracellular degradation system that is mediated by orchestrated functions of membranes and proteins. A genetic screen in Caenorhabditis elegans revealed that O-linked N-acetylglucosamine modification of the SNARE protein SNAP-29 negatively regulates SNARE-dependent fusion between autophagosomes and lysosomes. This regulatory mechanism is conserved in mammals.


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