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Resources » Paper

Ellis RE et al. (2014) Semin Cell Dev Biol "The regulation of spermatogenesis and sperm function in nematodes."

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  • Overview

    PMID:
    24718317
    DOI:
    10.1016/j.semcdb.2014.04.005
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00045099

    Ellis RE, & Stanfield GM (2014). The regulation of spermatogenesis and sperm function in nematodes. Semin Cell Dev Biol, 29, 17-30. doi:10.1016/j.semcdb.2014.04.005

    In the nematode C. elegans, both males and self-fertile hermaphrodites produce sperm. As a result, researchers have been able to use a broad range of genetic and genomic techniques to dissect all aspects of sperm development and function. Their results show that the early stages of spermatogenesis are controlled by transcriptional and translational processes, but later stages are dominated by protein kinases and phosphatases. Once spermatids are produced, they participate in many interactions with other cells - signals from the somatic gonad determine when sperm activate and begin to crawl, signals from the female reproductive tissues guide the sperm, and signals from sperm stimulate oocytes to mature and be ovulated. The sperm also show strong competitive interactions with other sperm and oocytes. Some of the molecules that mediate these processes have conserved functions in animal sperm, others are conserved proteins that have been adapted for new roles in nematode sperm, and some are novel proteins that provide insights into evolutionary change. The advent of new techniques should keep this system on the cutting edge of research in cellular and reproductive biology.


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