Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Askjaer P et al. (2014) WormBook "Modern techniques for the analysis of chromatin and nuclear organization in C. elegans."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Askjaer P et al. (2014) WormBook "Modern techniques for the analysis of chromatin and nuclear organization in C. elegans." (0)

  • Overview

    PMID:
    24706462
    DOI:
    10.1895/wormbook.1.169.1
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00045079

    Askjaer P, Ercan S, & Meister P (2014). Modern techniques for the analysis of chromatin and nuclear organization in C. elegans. WormBook, 1-35. doi:10.1895/wormbook.1.169.1

    In recent years, Caenorhabditis elegans has emerged as a new model to investigate the relationships between nuclear architecture, cellular differentiation, and organismal development. On one hand, C. elegans with its fixed lineage and transparent body is a great model organism to observe gene functions in vivo in specific cell types using microscopy. On the other hand, two different techniques have been applied in nematodes to identify binding sites for chromatin-associated proteins genome-wide: chromatin immunoprecipitation (ChIP), and Dam-mediated identification (DamID). We summarize here all three techniques together as they are complementary. We also highlight strengths and differences of the individual approaches.


    Tip: Seeing your name marked red? Please help us identify you.