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Resources » Paper

Vandenberg LN et al. (2013) Commun Integr Biol "It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry."

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  • Comments on Vandenberg LN et al. (2013) Commun Integr Biol "It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry." (0)

  • Overview

    PMID:
    24505508
    DOI:
    10.4161/cib.27155
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00044816

    Vandenberg LN, Lemire JM, & Levin M (2013). It's never too early to get it Right: A conserved role for the cytoskeleton in left-right asymmetry. Commun Integr Biol, 6, e27155. doi:10.4161/cib.27155

    For centuries, scientists and physicians have been captivated by the consistent left-right (LR) asymmetry of the heart, viscera, and brain. A recent study implicated tubulin proteins in establishing laterality in several experimental models, including asymmetric chemosensory receptor expression in C. elegans neurons, polarization of HL-60 human neutrophil-like cells in culture, and asymmetric organ placement in Xenopus. The same mutations that randomized asymmetry in these diverse systems also affect chirality in Arabidopsis, revealing a remarkable conservation of symmetry-breaking mechanisms among kingdoms. In Xenopus, tubulin mutants only affected LR patterning very early, suggesting that this axis is established shortly after fertilization. This addendum summarizes and extends the knowledge of the cytoskeleton's role in the patterning of the LR axis. Results from many species suggest a conserved role for the cytoskeleton as the initiator of asymmetry, and indicate that symmetry is first broken during early embryogenesis by an intracellular process.


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