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Resources » Paper

Hallberg B et al. (2013) Nat Rev Cancer "Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology."

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  • Comments on Hallberg B et al. (2013) Nat Rev Cancer "Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology." (0)

  • Overview

    PMID:
    24060861
    DOI:
    10.1038/nrc3580
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00044698

    Hallberg B, & Palmer RH (2013). Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology. Nat Rev Cancer, 13, 685-700. doi:10.1038/nrc3580

    The burgeoning field of anaplastic lymphoma kinase (ALK) in cancer encompasses many cancer types, from very rare cancers to the more prevalent non-small-cell lung cancer (NSCLC). The common activation of ALK has led to the use of the ALK tyrosine kinase inhibitor (TKI) crizotinib in a range of patient populations and to the rapid development of second-generation drugs targeting ALK. In this Review, we discuss our current understanding of ALK function in human cancer and the implications for tumour treatment.


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