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Resources » Paper

Robertson SM et al. (2012) Worm "Our evolving view of Wnt signaling in C. elegans: If two's company and three's a crowd, is four really necessary?"

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  • Comments on Robertson SM et al. (2012) Worm "Our evolving view of Wnt signaling in C. elegans: If two's company and three's a crowd, is four really necessary?" (0)

  • Overview

    PMID:
    24058829
    DOI:
    10.4161/worm.19156
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00044372

    Robertson SM, & Lin R (2012). Our evolving view of Wnt signaling in C. elegans: If two's company and three's a crowd, is four really necessary?. Worm, 1, 82-9. doi:10.4161/worm.19156

    In this commentary, we discuss how our recent paper by Yang et al. contributes a new wrinkle to the already somewhat curious Wnt signaling pathway in C. elegans. We begin with a historical perspective on the Wnt pathway in the worm, followed by a summary of the key salient point from Yang et al., 2011, namely demonstration of mutually inhibitory binding of a -catenin SYS-1 to the N-terminus and another -catenin WRM-1 to the C-terminus of the TCF protein POP-1, and a plausible structural explanation for these differential binding specificities. The mutually inhibitory binding creates one population of POP-1 that is bound by WRM-1, phosphorylated by the NLK kinase and exported from the nucleus, and another bound by coactivator SYS-1 that remains in the nucleus. We speculate on the evolutionary history of the four -catenins in C. elegans and suggest a possible link between multiple -catenin gene duplications and the requirement to reduce nuclear POP-1 levels to activate Wnt target genes.


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