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Resources » Paper

Miller, Elizabeth V et al. (2013) International Worm Meeting "fshr-1 provides a connection between the oxidative stress response and innate immunity in C.elegans."

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  • Comments on Miller, Elizabeth V et al. (2013) International Worm Meeting "fshr-1 provides a connection between the oxidative stress response and innate immunity in C.elegans." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00043254

    Miller, Elizabeth V, & Powell, Jennifer R (2013). fshr-1 provides a connection between the oxidative stress response and innate immunity in C.elegans presented in International Worm Meeting. Unpublished information; cite only with author permission.

    The initial response to infection is directed by the innate immune system, which identifies and kills invading microbial pathogens. Canonical immune defense is comprised of the induction of antimicrobial peptide effectors in response to pathogen detection by cell-surface receptors. In addition, many animals generate reactive oxygen species (ROS) upon the detection of microbes. ROS are highly reactive, and can interact with most cellular components, disturbing cellular function, and ultimately causing cell death. The same underlying mechanisms that make ROS an effective defense response against bacterial pathogens also make ROS dangerous for normal cellular functions because they are toxic to living cells. Thus, when ROS are generated as part of an immune response, detoxification enzymes must also be produced as part of an oxidative stress response so that the organism itself is not damaged by the ROS immune response. The G-protein coupled receptor FSHR-1 is an important component of the C.elegans innate immune response to infection by diverse pathogens. FSHR-1 acts in the intestine of the worms, the site of exposure to ingested pathogens. In C.elegans, fshr-1 is required for the induction of a range of antimicrobial compounds induced by Pseudomonas aeruginosa. Because ROS may also be critical in the defense against infection by microbial pathogens, we are investigating a connection between the fshr-1 response to P.aeruginosa with the oxidative stress response. We have analyzed the requirement for fshr-1 in the production and detoxification of ROS, and have established a dual role for FSHR-1 in oxidative stress and the innate immune response in C.elegans.

    Affiliation:
    - Gettysburg College, Gettysburg, PA.


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