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Resources » Paper

Kardos, Jordan et al. (2013) International Worm Meeting "The HIF-1 Pathway and organismal senescence."

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00043070

    Kardos, Jordan, & Nayak, Sudhir (2013). The HIF-1 Pathway and organismal senescence presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Several highly conserved pathways regulate senescence on both cellular and organismal levels across organisms. Hypoxia Inducible Factor-1 (HIF-1) is a transcriptional activator that functions as the cellular and physiological regulator of oxygen homeostasis under hypoxic conditions. HIF-1 has been shown to regulate a variety of important cellular processes in C. elegans including increased lifespan under hypoxic conditions. This has indicated a possible regulatory role of the HIF-1 pathway in organismal senescence. We tested the ability of CoCl2, a hypoxia mimicking molecule, to up regulate both HIF-1 expression and HIF-1 activity in C. elegans. We found that HIF-1 expression and activity were increased with CoCl2 exposure and resulted in a relative increase in both lifespan and brood size. Our data suggest that the relative increase in lifespan is indicative of a protective effect for post-mitotic ageing, while the relative increase in brood size is indicative of a protective effect for mitotic divisions.

    Affiliation:
    - The College of New Jersey Biology Dept., 2000 Pennington Road, Ewing, NJ 08628-0718


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