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Resources » Paper

Le Pen, Jeremie et al. (2013) International Worm Meeting "A deletion polymorphism in the C. elegans RIG-I homolog disables antiviral siRNA formation and immunity."

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  • Comments on Le Pen, Jeremie et al. (2013) International Worm Meeting "A deletion polymorphism in the C. elegans RIG-I homolog disables antiviral siRNA formation and immunity." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00043000

    Le Pen, Jeremie, Ashe, Alyson, Sarkies, Peter, Belicard, Tony, Cording, Amy, Lehrbach, Nicolas J., Felix, Marie-Anne, & Miska, Eric A. (2013). A deletion polymorphism in the C. elegans RIG-I homolog disables antiviral siRNA formation and immunity presented in International Worm Meeting. Unpublished information; cite only with author permission.

    RNA interference is an important effector of antiviral immunity in plants and animals. Yet, how Dicer can sense the foreign genomes of RNA viruses is still poorly understood. We address this question using the nematode Caenorhabditis elegans and its natural pathogen, the RNA virus Orsay. Genomic studies on C. elegans wild isolates permitted us to identify a common 159 base-pair deletion in the drh-1 gene as a major determinant of viral sensitivity. We show that DRH-1, a known Dicer interactor in C. elegans and the homologue of the human RIG-I receptor, is required for the generation of viral-derived siRNAs (viRNAs) by Dicer. It is well established in humans that RIG-I can sense foreign nucleic acids and trigger an interferon-based innate immunity response upon infection by RNA viruses such as Influenza. Our work with nematodes demonstrates that the conserved RNA binding domain of RIG-I has an ancient role in viral recognition outside of mammals. We therefore propose that RIG-I/DRH-1 acts as modular viral receptor that can couple viral sensing to different effector pathways including RNAi and interferon responses.

    Authors: Le Pen, Jeremie, Ashe, Alyson, Sarkies, Peter, Belicard, Tony, Cording, Amy, Lehrbach, Nicolas J., Felix, Marie-Anne, Miska, Eric A.

    Affiliations:
    - Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK
    - Department of Biochemistry, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN, UK


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