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Resources » Paper

Bai, Keliya et al. (2013) International Worm Meeting "The molecular genetics of epithelial cell morphogenesis- functional dissection of C. elegans homologue zyxin."

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  • Comments on Bai, Keliya et al. (2013) International Worm Meeting "The molecular genetics of epithelial cell morphogenesis- functional dissection of C. elegans homologue zyxin." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00042730

    Bai, Keliya, & Pettitt, Jonathan (2013). The molecular genetics of epithelial cell morphogenesis- functional dissection of C. elegans homologue zyxin presented in International Worm Meeting. Unpublished information; cite only with author permission.

    The zyxin family has been implicated in a wide range of cell behaviours, including cell adhesion and motility, and more recently in the regulation of Hippo signalling. All family members consist of three well-conserved LIM domains and an N-terminal, "pre-LIM" domain. Although highly conserved across animal phyla, the precise mechanisms by which these proteins function are not well understood. We are investigating the function of the sole C. elegans family member, ZYX-1. Genetic analysis indicates that ZYX-1 contributes to, but is not required for cadherin-mediated morphogenesis in C. elegans. Our data shows that ZYX-1 localises to adhesion junctions and becomes more strongly recruited as those junctions undergo actomysin-dependent tension. We are investigating the roles of these domains in the function and localisation of ZYX-1, as well as determining the mechanism by which ZYX-1 is recruited to adhesion junctions. In addition to its role in epithelia morphogenesis, we have also shown that it collaborates with other regulators of actin dynamics to coordinate the changes in cell shape and adhesion that accompany gastrulation.

    Affiliation:
    - School of Medical Sciences, University of Aberdeen, Aberdeen, Scotland, United Kingdom


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