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Resources » Paper

Sommer RJ et al. (2012) Wiley Interdiscip Rev Dev Biol "Nematode model systems in evolution and development."

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  • Overview

    PMID:
    23801489
    DOI:
    10.1002/wdev.33
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00042539

    Sommer RJ, & Bumbarger DJ (2012). Nematode model systems in evolution and development. Wiley Interdiscip Rev Dev Biol, 1, 389-400. doi:10.1002/wdev.33

    The free-living nematode Caenorhabditis elegans is one of the most important model organisms in all areas of modern biology. Using the knowledge about C. elegans as a baseline, nematodes are now intensively studied in evolution and development. Evolutionary developmental biology or for short, 'evo-devo' has been developed as a new research discipline during the last two decades to investigate how changes in developmental processes and mechanisms result in the modification of morphological structures and phenotypic novelty. In this article, we review the concepts that make nematode evo-devo a successful approach to evolutionary biology. We introduce selected model systems for nematode evo-devo and provide a detailed discussion of four selected case studies. The most striking finding of nematode evo-devo is the magnitude of developmental variation in the context of a conserved body plan. Detailed investigation of early embryogenesis, gonad formation, vulva development, and sex determination revealed that molecular mechanisms evolve rapidly, often in the context of a conserved body plan. These studies highlight the importance of developmental systems drift and neutrality in evolution.


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