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Resources » Paper

Lee JY et al. (2013) Gene "DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state."

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  • Comments on Lee JY et al. (2013) Gene "DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state." (0)

  • Overview

    PMID:
    23624124
    DOI:
    10.1016/j.gene.2013.04.032
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00042333

    Lee JY, Kim C, Kim J, & Park C (2013). DJR-1.2 of Caenorhabditis elegans is induced by DAF-16 in the dauer state. Gene, 524, 373-6. doi:10.1016/j.gene.2013.04.032

    Caenorhabditis elegans DJR-1.2, a homolog of human DJ-1, has recently been demonstrated to be a novel glyoxalase and protects worms against glyoxals. Here, we report that expression of DJR-1.2 is substantially increased during starvation as well as in the dauer stage. The induction of DJR-1.2 led to increased glyoxalase activity in the dauer state, thereby increasing protection against glyoxals. The induction is regulated by DAF-16, a transcriptional regulator implicated in oxidative stress and normal lifespan.


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