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Resources » Paper

Uno M et al. (2013) Cell Rep "A fasting-responsive signaling pathway that extends life span in C. elegans."

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  • Comments on Uno M et al. (2013) Cell Rep "A fasting-responsive signaling pathway that extends life span in C. elegans." (0)

  • Overview

    PMID:
    23352664
    DOI:
    10.1016/j.celrep.2012.12.018
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00041960

    Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, Ebisuya M, Matsumoto K, & Nishida E (2013). A fasting-responsive signaling pathway that extends life span in C. elegans. Cell Rep, 3, 79-91. doi:10.1016/j.celrep.2012.12.018

    Intermittent fasting is one of the most effective dietary restriction regimens that extend life span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce the fasting stimulus remain largely unknown. Through a comprehensive transcriptome analysis in C. elegans, we find that along with the FOXO transcription factor DAF-16, AP-1 (JUN-1/FOS-1) plays a central role in fasting-induced transcriptional changes. KGB-1, one of the C. elegans JNKs, acts as an activator of AP-1 and is activated in response to fasting. KGB-1 and AP-1 are involved in intermittent fasting-induced longevity. Fasting-induced upregulation of the components of the SCF E3 ubiquitin ligase complex via AP-1 and DAF-16 enhances protein ubiquitination and reduces protein carbonylation. Our results thus identify a fasting-responsive KGB-1/AP-1 signaling pathway, which, together with DAF-16, causes transcriptional changes that mediate longevity, partly through regulating proteostasis.

    Authors: Uno M, Honjoh S, Matsuda M, Hoshikawa H, Kishimoto S, Yamamoto T, Ebisuya M, Matsumoto K, Nishida E


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