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Resources » Paper

Antebi A (2013) Exp Gerontol "Regulation of longevity by the reproductive system."

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  • Overview

    PMID:
    23063987
    DOI:
    10.1016/j.exger.2012.09.009
    Status:
    Publication type:
    Review
    WormBase ID:
    WBPaper00041640

    Antebi A (2013). Regulation of longevity by the reproductive system. Exp Gerontol, 48, 596-602. doi:10.1016/j.exger.2012.09.009

    Pioneering work in model organisms reveals that the reproductive system is involved not only in propagation of the species but also regulates organismal metabolism and longevity. In C. elegans, prevention of germline stem cell proliferation results in a 60% extension of lifespan, termed gonadal longevity. Gonadal longevity relies on the transcriptional activities of steroid nuclear receptor DAF-12, the FOXO transcription factor homolog DAF-16, the FOXA transcription factor homolog PHA-4, and the HNF-4-like nuclear receptor NHR-80. These transcription factors work in an integrated transcriptional network to regulate fatty acid lipolysis, autophagy, stress resistance and other processes, which altogether enhance homeostasis and extend life. Because the reproductive system also regulates longevity in other species, studies in C. elegans may shed light on ancient mechanisms governing reproduction and survival.


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