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Resources » Paper

Feng W et al. (2012) Sci China Life Sci "RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans."

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  • Comments on Feng W et al. (2012) Sci China Life Sci "RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans." (0)

  • Overview

    PMID:
    22527519
    DOI:
    10.1007/s11427-012-4296-9
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00041003

    Feng W, Liang T, Yu J, Zhou W, Zhang Y, Wu Z, & Xu T (2012). RAB-27 and its effector RBF-1 regulate the tethering and docking steps of DCV exocytosis in C. elegans. Sci China Life Sci, 55, 228-35. doi:10.1007/s11427-012-4296-9

    The molecular mechanisms by which dense core vesicles (DCVs) translocate, tether, dock and prime are poorly understood. In this study, Caenorhabditis elegans was used as a model organism to study the function of Rab proteins and their effectors in DCV exocytosis. RAB-27/AEX-6, but not RAB-3, was found to be required for peptide release from neurons. By analyzing the movement of DCVs approaching the plasma membrane using total internal reflection fluorescence microscopy, we demonstrated that RAB-27/AEX-6 is involved in the tethering of DCVs and that its effector rabphilin/RBF-1 is required for the initial tethering and subsequent stabilization by docking.


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