Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Zahler AM (2012) WormBook "Pre-mRNA splicing and its regulation in Caenorhabditis elegans."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Zahler AM (2012) WormBook "Pre-mRNA splicing and its regulation in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    22467343
    DOI:
    10.1895/wormbook.1.31.2
    Status:
    Publication type:
    Wormbook, Review
    WormBase ID:
    WBPaper00040943

    Zahler AM (2012). Pre-mRNA splicing and its regulation in Caenorhabditis elegans. WormBook, 1-21. doi:10.1895/wormbook.1.31.2

    Alternative splicing is a common mechanism for the generation of multiple isoforms of proteins. It can function to expand the proteome of an organism and can serve as a way to turn off gene expression after transcription. This review focuses on splicing, its regulation and the progress in this field achieved through studies in C. elegans. Recent experiments, including RNA-Seq to uncover and measure the extent of alternative splicing, comparative genomics to identify splicing regulatory elements, and the development of elegant genetic screens using fluorescent reporter constructs, have increased our understanding of the cis-acting sequences that regulate alternative splicing and the trans-acting protein factors that bind to these sequences. The topics covered in this review include constitutive splicing factors, identification of alternatively spliced genes, alternative splicing regulation and the coupling of alternative splicing to nonsense-mediated decay. The significant progress towards uncovering the alternative splicing code in this organism is discussed.


    Tip: Seeing your name marked red? Please help us identify you.