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Resources » Paper

Cai WJ et al. (2011) PLoS One "Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans."

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  • Comments on Cai WJ et al. (2011) PLoS One "Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans." (0)

  • Overview

    PMID:
    22216122
    DOI:
    10.1371/journal.pone.0028835
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00040566

    Cai WJ, Huang JH, Zhang SQ, Wu B, Kapahi P, Zhang XM, & Shen ZY (2011). Icariin and its derivative icariside II extend healthspan via insulin/IGF-1 pathway in C. elegans. PLoS One, 6, e28835. doi:10.1371/journal.pone.0028835

    Compounds that delay aging might also postpone age-related diseases and extend healthspan in humans. Icariin is a flavonol extracted from several plant species of the Epimedium family. The icariin and its metabolic derivatives have been shown to exert wide protective effects in age-related diseases. However, whether icariin and its derivatives have the potency of delaying aging remains unclear. Here, we report that icariin and its derivative icariside II extend C. elegans lifespan. Using HPLC, we found high level of icariside II in the animals treated with icariin, suggesting icariside II is the bioactive form in vivo of icariin. Icariside II also increased the thermo and oxidative stress tolerance, slowed locomotion decline in late adulthood and delayed the onset of paralysis mediated by polyQ and A(1-42) proteotoxicity. The lifespan extension effect of icariside II is dependent on the insulin/IGF-1 signaling (IIS) since the daf-16(mu86) and daf-2(e1370) failed to show any lifespan extension upon icariside II treatment. Consistently, icariside II treatment upregulates the expression of DAF-16 targets in the wild-type. Moreover, our data suggests that the heat shock transcription factor HSF-1 has a role in icariside II-dependent lifespan extension further implicating the IIS pathway. In conclusion, we demonstrate a novel natural compound, icariside II as the bioactive form of icariin, extends the healthspan via IIS pathway in C. elegans.


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