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Resources » Paper

Ahn, Byungchan et al. (2011) International Worm Meeting "The Caenorhabditis elegans WRN-1 RecQ helicase participates in both DNA damage signaling and DNA Repair."

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  • Comments on Ahn, Byungchan et al. (2011) International Worm Meeting "The Caenorhabditis elegans WRN-1 RecQ helicase participates in both DNA damage signaling and DNA Repair." (0)

  • Overview

    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00038903

    Ahn, Byungchan, Hyun, M, Park, S, Kim, E, & Park, H (2011). The Caenorhabditis elegans WRN-1 RecQ helicase participates in both DNA damage signaling and DNA Repair presented in International Worm Meeting. Unpublished information; cite only with author permission.

    RecQ helicases play essential roles in maintenance of genomic stability from E. coli to humans. The RecQ helicases interact with proteins involved in DNA metabolic pathways such DNA repair, recombination, and replication. We found that C. elegans wrn-1 mutant is more sensitive to CPT than N2 and that the wrn-1 mutant failed to arrest the S-phase since DNA synthesis was continued following CPT treatment. In addition, more DNA strand breaks accumulate in the wrn-1 mutant. These data suggest that WRN-1 is involved in DSB processing and/or DNA damage signaling. WRN-1 colocalized with CeRPA in nucleus in germ line cells following CPT, but CeRPA foci formation was independent of WRN-1. In addition, WRN-1 foci formation was not affected in atm-1 and atl-1 mutants and WRN-1 was required for phoshorylation of CHK-1 induced by DSBs. WRN-1 also colocalized with RAD51. These results suggest that WRN-1 functions downstream of RPA and upstream of ATM-1/ATL-1 and CHK-1 in the DSB checkpoint pathway and is in involved in a DNA repair pathway with RAD51.

    Affiliation:
    - Dept Life Sci, Univ Ulsan, Ulsan, Korea


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