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Comments on Axel A Elling et al. (2010) Evolutionary Biology of Caenorhabditis and Other Nematodes "COMPARATIVE GENOMICS BETWEEN CAENORHABDITIS ELEGANS AND HETERODERA GLYCINES" (0)
Overview
Axel A Elling, & Thomas J Baum (2010). COMPARATIVE GENOMICS BETWEEN CAENORHABDITIS ELEGANS AND HETERODERA GLYCINES presented in Evolutionary Biology of Caenorhabditis and Other Nematodes. Unpublished information; cite only with author permission.
Parasitic nematodes have a major impact on human and animal health and crop productivity. Many of the most important parasitic nematodes are endoparasites, which makes them generally inaccessible to molecular techniques once they are inside their hosts. With the exception of RNA interference, forward and reverse genetics and transgenesis have so far proven to be impossible with parasitic nematodes, which represents a significant technological hurdle. Comparative genomics between the model nematode Caenorhabditis elegans and parasitic species is a powerful approach to circumvent some of these problems and to gain insights into fundamental biological processes that are conserved in the Nematoda. We have conducted a comparative analysis between C. elegans and the plant-parasitic nematode Heterodera glycines. Using microarrays and sequence analyses we identified 788 H. glycines candidate genes with putative roles in parasitism for further studies. Furthermore, we found that a significant number of genes that are enriched for the dauer stage in C. elegans have putative orthologs in H. glycines but that their expression signatures were not uniformly conserved when the developmentally arrested infective stage of H. glycines and the C. elegans dauer stage were compared. This suggests that the molecular mechanisms governing developmental arrest in C. elegans and H. glycines might have undergone more divergent evolution than previously thought and points at the need for more detailed analyses of parasitic species. Sequencing the genomes of more non-parasitic and parasitic nematodes to capture the enormous diversity in trophic ecology, habitats and life styles found in the phylum Nematoda will allow a better understanding of the evolutionary changes that have occurred between the dauer stage in C. elegans and the infective stage of parasitic nematodes.
