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Resources » Paper

Hughes, Samantha L. et al. (2009) International Worm Meeting "Novel regulators of RNT-1/BRO-1 induced hyperplasia."

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  • Comments on Hughes, Samantha L. et al. (2009) International Worm Meeting "Novel regulators of RNT-1/BRO-1 induced hyperplasia." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00034283

    Hughes, Samantha L., Maxwell, Sara, & Woollard, Alison (2009). Novel regulators of RNT-1/BRO-1 induced hyperplasia presented in International Worm Meeting. Unpublished information; cite only with author permission.

    The balance between cell proliferation and differentiation is controlled, in part, by a complex of runx and CBFb. In C. elegans rnt-1 and bro-1 (homologs of mammalian runx and CBFb) are expressed in seam cells and control their divisions in a stem-like pattern. During development, seam cells undergo asymmetric divisions to produce daughter cells which fuse with the hypodermal syncytium. Sensory rays in male tails are formed from precursors which arise as a consequence of additional seam cell divisions. Nematodes containing an integrated array of rnt-1 and bro-1, AW257, have an excessive number of seam cells; approximately 40 compared to a wild type number of 16. Seam cell hyperplasia laterally expands the seam giving the nematode a dumpy phenotype. Suppressors of the hyperplasia are relatively easy to isolate as they would arise as a return to wild type appearance. Here we present the results of a full genome RNAi screen to identify suppressors of hyperplasia.


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