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Resources » Paper

Ibourk, Mouna et al. (2009) International Worm Meeting "Mechanistic study of CACN-1, a novel regulator of cell migration."

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  • Comments on Ibourk, Mouna et al. (2009) International Worm Meeting "Mechanistic study of CACN-1, a novel regulator of cell migration." (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00033506

    Ibourk, Mouna, & Cram, Erin (2009). Mechanistic study of CACN-1, a novel regulator of cell migration presented in International Worm Meeting. Unpublished information; cite only with author permission.

    Cell migration is of fundamental importance, essential for embryonic development and tissue and organ morphogenesis in all animals. CACN-1 is a novel and well-conserved protein that is required for distal tip cell migration and gonad morphogenesis in the C. elegans nematode worm. Previous studies have identified proteins that interact in complexes to control cell behaviors such as cell migration. In our study, we conducted a genome wide yeast two hybrid screen to identify specific proteins that interact with CACN-1 in vivo. We have identified several possible interactors of CACN-1, including UNC-15/paramyosin and MIG-5/Dishevelled. UNC-15 and MIG-5 will now be further tested by RNAi to determine if they are required for DTC migration. Finally, the interaction between CACN-1 and the candidate proteins will be confirmed biochemically using a GST pull-down experiment. Results from this study will improve our understanding of the fundamental regulation of cell migration during animal development and provide new and important insights into the mechanisms of cell migration in pathologic conditions such as metastatic cancer.


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