Questions, Feedback & Help
Send us an email and we'll get back to you ASAP. Or you can read our Frequently Asked Questions.
  • page settings
  • hide sidebar
  • show empty fields
  • layout
  • (too narrow)
  • open all
  • close all
Resources » Paper

Arya U et al. (2009) Exp Gerontol "Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans."

  • History

  • Referenced

  • Tree Display

  • My Favorites

  • My Library

  • Comments on Arya U et al. (2009) Exp Gerontol "Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans." (0)

  • Overview

    PMID:
    19264117
    DOI:
    10.1016/j.exger.2009.02.010
    Status:
    Publication type:
    Journal_article
    WormBase ID:
    WBPaper00032959

    Arya U, Dwivedi H, & Subramaniam JR (2009). Reserpine ameliorates Abeta toxicity in the Alzheimer's disease model in Caenorhabditis elegans. Exp Gerontol, 44, 462-6. doi:10.1016/j.exger.2009.02.010

    Earlier we have reported that reserpine, an antihypertensive drug, known to downregulate biogenic amines through inhibition of the vesicular monoamine transporter (VMAT), increases longevity of Caenorhabditis elegans with a high quality of life, namely, enhanced and prolonged mobility (Srivastava et al., 2008). As neurodegenerative diseases are of adult onset, we addressed the protective ability of reserpine against neurodegenerative diseases, especially Alzheimer's disease (AD). In the well established AD model in C. elegans, Amyloid beta (Abeta) is expressed in the muscles and Abeta toxicity is manifested as paralysis (Link, 1995). In this model, reserpine significantly delayed paralysis and increased the longevity. In addition, reserpine provided thermotolerance, but interestingly the Abeta transcript and expression levels remains grossly unchanged.


    Tip: Seeing your name marked red? Please help us identify you.