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Resources » Paper

Francis Amrit et al. (2008) C.elegans Aging, Stress, Pathogenesis, and Heterochrony Meeting "Evolution and Significance of DAF-16 signalling in the Caenorhabditis genus"

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  • Comments on Francis Amrit et al. (2008) C.elegans Aging, Stress, Pathogenesis, and Heterochrony Meeting "Evolution and Significance of DAF-16 signalling in the Caenorhabditis genus" (0)

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    Status:
    Publication type:
    Meeting_abstract
    WormBase ID:
    WBPaper00032650

    Francis Amrit, & Robin May (2008). Evolution and Significance of DAF-16 signalling in the Caenorhabditis genus presented in C.elegans Aging, Stress, Pathogenesis, and Heterochrony Meeting. Unpublished information; cite only with author permission.

    In nematodes, lifespan and stress resistance have been shown to have both a gender specific and species specific variability and previous work has suggested that there is a common molecular mechanism or a molecular link which governs these processes. Using various Caenorhabditis species we are investigating whether the transcription factor DAF-16, a downstream component of the Insulin like/IGF-1 signalling pathway, acts as this molecular link. DAF-16 is orthologous to the FOXO family of transcription factors in mammals and is thought to play a key role in stress response, immune response and ageing by controlling expression of several hundred genes. We have shown that hermaphrodite species within the Caenorhabditis genus seem to age faster and possess a weaker immune response in comparison to the male/female (gonochoristic) species. This work focuses on establishing that it is the difference in expression of the DAF-16 transcription factor and its activity which is responsible for the difference in immune response and hence the difference in ageing among the various Caenorhabditid species. We propose that this could also explain the evolutionary conundrum of post-reproductive ageing since enhanced immunity would also increase lifespan even after the animal has reproduced.


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